Faculty of the Division of Endocrinology & Metabolism
Karl Y. Hostetler, M.D.
Adjunct Professor of Medicine
Keywords: antivirals, acyclic nucleoside phosphonates, herpes virus, hepatitis, HIV, cytomegalovirus
My laboratory is interested in the design, synthesis and evaluation of novel orally active analogs of acyclic nucleoside phosphonate antivirals for cytomegalovirus, herpes simplex, orf virus, hepatitis B and C, HIV-1, Epstein Barr virus, BK virus and poxviruses such as smallpox, monkeypox, cowpox, ectromelia, and vaccinia. We have also developed novel antiproliferative acyclic nucleoside phosphonates for human cervical cancer and other drugs which are being evaluated by the National Cancer Institute because of their high activity in the 60 human cancer cell screen. Finally, with our collaborators in the Dept. of Ophthalmology, we are also working on long duration of action strategies for viral and proliferative diseases of the retina. Our research is supported by the NIAID, NCI and the NEI.
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