Faculty of the Division of Endocrinology & Metabolism
M. Geoffrey Rosenfeld, M.D.
Professor of Medicine, and Professor of the Howard Hughes Medical Institute
Keywords: gene expression, co-activators, co-repressors, transcription, nuclear hormone receptors, pituitary development
We are investigating the molecular strategies used to generate genome-wide, integrated transcriptional responses to the vast signaling network that regulates development and homeostasis. We are using genetic, biochemical and biological approaches to define the strategies used by the human body to specify modifications to development and differentiation of cells when genes are expressed. Our work has revealed unexpected gene-specific strategies that link regulated gene responses to other cellular response programs, including DNA damage and DNA repair. Defining these strategies has suggested new approaches to diseases, including growth defects, diabetes, arteriosclerosis, and several prevalent forms of cancer.
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