Faculty of the Division of Endocrinology & Metabolism
Nicholas J. Webster, Ph.D.
Associate Vice Chancellor for Research Facilities,
Professor of Medicine, and Interim Chief of Endocrinology
Keywords: Hypothalamus, pituitary, reproduction, GnRH, gonadotropins, RNA
splicing, neurotrophins, insulin receptor
Our research focuses on the mechanism of hormonal regulation of different cellular processes. At the genomic level, we are interested in how hormones can regulate alternative splicing of mRNAs. At the cellular level, we are interested in how the hypothalamic neuropeptide gonadotropin releasing hormone stimulates pituitary gonadotropes to synthesize and secrete LH and FSH in response to varying pulse frequency and amplitude. At the physiological level, we are interested in how metabolic derangements such as caloric restriction or obesity alter reproductive function. At the therapeutic level, we are using combinatorial chemistry to develop agonists for neurotrophin receptors and testing them in mouse models of Alzheimer's Disease and traumatic brain injury.
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