Among his 350 publications, Dr. Porte is best known for his contributions to our understanding of the regulation of the endocrine pancreas and its role in type 2 diabetes and obesity, and the importance of hyperglycemia to the neuropathy of diabetes. His present interests are: 1. The mechanisms for the regulation of the alpha cells secretion of glucagon by the CNS, and beta-cell related hormones and neural factors, 2. The role of insulin in brain function, glucose homeostasis, and body weight regulation, and 3. The importance of the physiology of the incretin hormones in plasma glucose control and diabetes therapy.