Our mission is to develop new ways to detect and treat insulin resistance.
Our Research
Insulin resistance causes the epidemic diseases of our era, but it is invisible even to trained clinical eyes. We apply the tools of functional genomics, bioinformatics, and human genetics in a collaborative, multi-disciplinary research environment to identify and treat people with insulin resistance. Read more:
Lab News & Announcements
- April 2025: Our recent work identifying the AF-1 domain of PPARG as an insulin-sensitizing therapeutic target was highlighted as Diabetes Paper of the Month and the topic of a recent DiabetesBio episode - an official podcast from the American Diabetes Association. Give it a listen to hear more from Dr. Majithia!
- February 2025: Welcome Postdoctoral Researcher Kavita Koshta! Kavita brings expertise in adipocyte biology and mouse models of metabolism.
- January 2025: Our work to characterize an alternatively translated isoform of PPARG and the effect on its activity has been published in Diabetes. Take a look:
- "An alternatively translated isoform of PPARG proposes AF-1 domain inhibition as an insulin sensitization target." Diabetes 2025. PDF.
- January 2025: Our work to profile plasma metabolites from patients with type 2 diabetes has been published in Diabetes Care. Check it out:
- "Plasma Lipid Metabolites, Clinical Glycemic Predictors, and Incident Type 2 Diabetes." Diabetes Care 2025. PDF.
- January 2025: Welcome AI expert and Bioinformatician Achint Kumar and Undergraduate Researcher Danielle Dang! Achint and Danielle are both interested in using AI to improve clinical decision-making and will work together with graduate student Emily on our new insulin-dosing project: aiDose.