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Division of Endocrinology & Metabolism Endocrinology & Metabolism
  1. Division of Endocrinology & Metabolism
  2. Research
  3. Wei Ying Lab
  4. Publications

Publications

2022

Gao H, Jin Z, Bandyopadhyay G, Wang G, Zhang D, Rocha KCE, Liu X, Zhao H, Kisseleva T, Brenner DA, Karin M, Ying W. Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis. Cell Metab. 2022 Aug 2;34(8):1201-1213.e5. doi: 10.1016/j.cmet.2022.07.006. PubMed PMID: 35921818; PubMed Central PMCID: PMC9365100.

Gao H, Jin Z, Bandyopadhyay G, Cunha E Rocha K, Liu X, Zhao H, Zhang D, Jouihan H, Pourshahian S, Kisseleva T, Brenner DA, Ying W, Olefsky JM. MiR-690 treatment causes decreased fibrosis and steatosis and restores specific Kupffer cell functions in NASH. Cell Metab. 2022 Jul 5;34(7):978-990.e4. doi: 10.1016/j.cmet.2022.05.008. Epub 2022 Jun 13. PubMed PMID: 35700738; PubMed Central PMCID: PMC9262870.

Luo Z, Ji Y, Zhang D, Gao H, Jin Z, Yang M, Ying W. Microbial DNA enrichment promotes liver steatosis and fibrosis in the course of non-alcoholic steatohepatitis. Acta Physiol (Oxf). 2022 Jul;235(3):e13827. doi: 10.1111/apha.13827. Epub 2022 May 10. PubMed PMID: 35500155; PubMed Central PMCID: PMC9335517.

Cao M, Isaac R, Yan W, Ruan X, Jiang L, Wan Y, Wang J, Wang E, Caron C, Neben S, Drygin D, Pizzo DP, Wu X, Liu X, Chin AR, Fong MY, Gao Z, Guo K, Fadare O, Schwab RB, Yuan Y, Yost SE, Mortimer J, Zhong W, Ying W, Bui JD, Sears DD, Olefsky JM, Wang SE. Cancer-cell-secreted extracellular vesicles suppress insulin secretion through miR-122 to impair systemic glucose homeostasis and contribute to tumour growth. Nat Cell Biol. 2022 Jun;24(6):954-967. doi: 10.1038/s41556-022-00919-7. Epub 2022 May 30. PubMed PMID: 35637408; PubMed Central PMCID: PMC9233030. 

Gao H, Jin Z, Tang K, Ji Y, Suarez J, Suarez JA, Cunha E Rocha K, Zhang D, Dillmann WH, Mahata SK, Ying W. Microbial DNA Enrichment Promotes Adrenomedullary Inflammation, Catecholamine Secretion, and Hypertension in Obese Mice. J Am Heart Assoc. 2022 Feb 15;11(4):e024561. doi: 10.1161/JAHA.121.024561. Epub 2022 Feb 3. PubMed PMID: 35112881; PubMed Central PMCID: PMC9245808.

Gao H, Luo Z, Ji Y, Tang K, Jin Z, Ly C, Sears DD, Mahata S, Ying W. Accumulation of microbial DNAs promotes to islet inflammation and β cell abnormalities in obesity in mice. Nat Commun. 2022 Jan 28;13(1):565. doi: 10.1038/s41467-022-28239-2. PubMed PMID: 35091566; PubMed Central PMCID: PMC8799656.

Liu MA, Shahabi S, Jati S, Tang K, Gao H, Jin Z, Miller W, Meunier FA, Ying W, van den Bogaart G, Ghosh G, Mahata SK. Gut microbial DNA and immune checkpoint gene Vsig4/CRIg are key antagonistic players in healthy aging and age-associated development of hypertension and diabetes. Front Endocrinol (Lausanne). 2022;13:1037465. doi: 10.3389/fendo.2022.1037465. eCollection 2022. PubMed PMID: 36440192; PubMed Central PMCID: PMC9691654.

Xian H, Watari K, Sanchez-Lopez E, Offenberger J, Onyuru J, Sampath H, Ying W, Hoffman HM, Shadel GS, Karin M. Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling. Immunity. 2022 Aug 9;55(8):1370-1385.e8. doi: 10.1016/j.immuni.2022.06.007. Epub 2022 Jul 13. PubMed PMID: 35835107; PubMed Central PMCID: PMC9378606. 

2021

Isaac R, Reis FCG, Ying W, Olefsky JM. Exosomes as mediators of intercellular crosstalk in metabolism. Cell Metab. 2021 Sep 7;33(9):1744-1762. doi: 10.1016/j.cmet.2021.08.006. Review. PubMed PMID: 34496230; PubMed Central PMCID: PMC8428804.

Ji Y, Luo Z, Gao H, Dos Reis FCG, Bandyopadhyay G, Jin Z, Manda KA, Isaac R, Yang M, Fu W, Ying W, Olefsky JM. Hepatocyte-derived exosomes from early onset obese mice promote insulin sensitivity through miR-3075. Nat Metab. 2021 Sep;3(9):1163-1174. doi: 10.1038/s42255-021-00444-1. Epub 2021 Sep 6. PubMed PMID: 34489604; PubMed Central PMCID: PMC8460610.

Luo Z, Ji Y, Gao H, Gomes Dos Reis FC, Bandyopadhyay G, Jin Z, Ly C, Chang YJ, Zhang D, Kumar D, Ying W. CRIg+ Macrophages Prevent Gut Microbial DNA-Containing Extracellular Vesicle-Induced Tissue Inflammation and Insulin Resistance. Gastroenterology. 2021 Feb;160(3):863-874. doi: 10.1053/j.gastro.2020.10.042. Epub 2020 Nov 2. PubMed PMID: 33152356; PubMed Central PMCID: PMC7878308.

Muntjewerff EM, Tang K, Lutter L, Christoffersson G, Nicolasen MJT, Gao H, Katkar GD, Das S, Ter Beest M, Ying W, Ghosh P, El Aidy S, Oldenburg B, van den Bogaart G, Mahata SK. Chromogranin A regulates gut permeability via the antagonistic actions of its proteolytic peptides. Acta Physiol (Oxf). 2021 Jun;232(2):e13655. doi: 10.1111/apha.13655. Epub 2021 May 6. PubMed PMID: 33783968; PubMed Central PMCID: PMC8341099.

Ying W, Tang K, Avolio E, Schilling JM, Pasqua T, Liu MA, Cheng H, Gao H, Zhang J, Mahata S, Ko MS, Bandyopadhyay G, Das S, Roth DM, Sahoo D, Webster NJG, Sheikh F, Ghosh G, Patel HH, Ghosh P, van den Bogaart G, Mahata SK. Immunosuppression of Macrophages Underlies the Cardioprotective Effects of CST (Catestatin). Hypertension. 2021 May 5;77(5):1670-1682. doi: 10.1161/HYPERTENSIONAHA.120.16809. Epub 2021 Apr 7. PubMed PMID: 33826401; PubMed Central PMCID: PMC8116433.

Ying W, Gao H, Dos Reis FCG, Bandyopadhyay G, Ofrecio JM, Luo Z, Ji Y, Jin Z, Ly C, Olefsky JM. MiR-690, an exosomal-derived miRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice. Cell Metab. 2021 Apr 6;33(4):781-790.e5. doi: 10.1016/j.cmet.2020.12.019. Epub 2021 Jan 14. PubMed PMID: 33450179; PubMed Central PMCID: PMC8035248.

Gao H, Luo Z, Jin Z, Ji Y, Ying W. Adipose Tissue Macrophages Modulate Obesity-Associated β Cell Adaptations through Secreted miRNA-Containing Extracellular Vesicles. Cells. 2021 Sep 17;10(9). doi: 10.3390/cells10092451. PubMed PMID: 34572101; PubMed Central PMCID: PMC8472266.

2020

Ying W, Fu W, Lee YS, Olefsky JM. The role of macrophages in obesity-associated islet inflammation and β-cell abnormalities. Nat Rev Endocrinol. 2020 Feb;16(2):81-90. doi: 10.1038/s41574-019-0286-3. Epub 2019 Dec 13. Review. PubMed PMID: 31836875; PubMed Central PMCID: PMC8315273. 

2019

Ying W, Lee YS, Dong Y, Seidman JS, Yang M, Isaac R, Seo JB, Yang BH, Wollam J, Riopel M, McNelis J, Glass CK, Olefsky JM, Fu W. Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting β Cell Proliferation and Function in Obesity. Cell Metab. 2019 Feb 5;29(2):457-474.e5. doi: 10.1016/j.cmet.2018.12.003. Epub 2018 Dec 27. PubMed PMID: 30595478; PubMed Central PMCID: PMC6701710.

Wollam J, Riopel M, Xu YJ, Johnson AMF, Ofrecio JM, Ying W, El Ouarrat D, Chan LS, Han AW, Mahmood NA, Ryan CN, Lee YS, Watrous JD, Chordia MD, Pan D, Jain M, Olefsky JM. Microbiota-Produced N-Formyl Peptide fMLF Promotes Obesity-Induced Glucose Intolerance. Diabetes. 2019 Jul;68(7):1415-1426. doi: 10.2337/db18-1307. Epub 2019 Apr 22. PubMed PMID: 31010956; PubMed Central PMCID: PMC6609982.

2018

Hernandez-Carretero A, Weber N, La Frano MR, Ying W, Lantero Rodriguez J, Sears DD, Wallenius V, Börgeson E, Newman JW, Osborn O. Obesity-induced changes in lipid mediators persist after weight loss. Int J Obes (Lond). 2018 Apr;42(4):728-736. doi: 10.1038/ijo.2017.266. Epub 2017 Nov 1. PubMed PMID: 29089614; PubMed Central PMCID: PMC6055936.

Ying W, Mahata S, Bandyopadhyay GK, Zhou Z, Wollam J, Vu J, Mayoral R, Chi NW, Webster NJG, Corti A, Mahata SK. Catestatin Inhibits Obesity-Induced Macrophage Infiltration and Inflammation in the Liver and Suppresses Hepatic Glucose Production, Leading to Improved Insulin Sensitivity. Diabetes. 2018 May;67(5):841-848. doi: 10.2337/db17-0788. Epub 2018 Feb 6. PubMed PMID: 29432123; PubMed Central PMCID: PMC6463753.

2017

Ying W, Riopel M, Bandyopadhyay G, Dong Y, Birmingham A, Seo JB, Ofrecio JM, Wollam J, Hernandez-Carretero A, Fu W, Li P, Olefsky JM. Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity. Cell. 2017 Oct 5;171(2):372-384.e12. doi: 10.1016/j.cell.2017.08.035. Epub 2017 Sep 21. PubMed PMID: 28942920.

Ying W, Wollam J, Ofrecio JM, Bandyopadhyay G, El Ouarrat D, Lee YS, Oh DY, Li P, Osborn O, Olefsky JM. Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling. J Clin Invest. 2017 Mar 1;127(3):1019-1030. doi: 10.1172/JCI90350. Epub 2017 Feb 13. PubMed PMID: 28192375; PubMed Central PMCID: PMC5330737.

MicroRNA-Regulated Immune Cell Function in Obese Adipose Tissue. In: Handbook of Nutrition, Diet, and Epigenetics Cham: Springer; 2017. p.1-18.

Li C, Ying W, Huang Z, Brehm T, Morin A, Vella AT, Zhou B. IRF6 Regulates Alternative Activation by Suppressing PPARγ in Male Murine Macrophages. Endocrinology. 2017 Sep 1;158(9):2837-2847. doi: 10.1210/en.2017-00053. PubMed PMID: 28645193; PubMed Central PMCID: PMC5659664.

Mishra PK, Ying W, Nandi SS, Bandyopadhyay GK, Patel KK, Mahata SK. Diabetic Cardiomyopathy: An Immunometabolic Perspective. Front Endocrinol (Lausanne). 2017;8:72. doi: 10.3389/fendo.2017.00072. eCollection 2017. Review. PubMed PMID: 28439258; PubMed Central PMCID: PMC5384479.